RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
Pde1a
RNA ID
RNA Type
mRNA
Alteration Pattern
down regulation
Species
rattus norvegicus
Detection Methods
qRT-PCR; Dual-luciferase reporter assay; ELISA etc.
Target
Pde1a
Pathway
NA
PubMed ID
Title
MiR-541-5p regulates lung fibrosis by targeting cyclic nucleotide phosphodiesterase 1A
Year
2017
Function
Cyclic nucleotide phosphodiesterase 1A (PDE1A) can stimulate lung fibroblasts to undergo myofibroblastic changes. MiR-541-5p expression is downregulated in TGF-B-treated lung fibroblasts and the rat pulmonary fibrosis model. Overexpression of miR-541-5p in lung fibroblasts inhibited mortality of human lung fibroblasts by targeting PDE1A.